• Our third finding is the interconnection

  2020-08-04

  

  Our third finding is the interconnection with eNOS uncoupling and autophagic flux impairment in low SS exposed ECs. We observed that improvement of eNOS uncoupling did not restore autophagic flux, which was validated by the result that low SS induced eNOS uncoupling was nonetheless decreased by L-NA

• br Covalent reversible post translational modification of ce

  2020-08-04

  

  Covalent, reversible, post-translational modification of cellular proteins with the small modifier, ubiquitin (Ub), regulates virtually every known cellular process in eukaryotes. A protein may be modified with a single Ub (mono-ubiquitination), several single Ubs, or multiple Ubs that are covalen

• In addition to supporting the catalytic function of

  2020-08-04

  

  In addition to supporting the catalytic function of BRCC36, KIAA0157 and Abraxas also serve scaffolding functions to recruit the BRCC45–MERIT40 heterodimer and the targeting subunits RAP80 or SHMT2. Surprisingly, super dimerization is not only required for the catalytic function of BRCC36 but it is 

• In three separate studies Ferr s group pointed at

  2020-08-04

  

  In three separate studies Ferré\'s group pointed at a relation between adenosine and its two main receptor subtypes in the NU 7026 (A1R and A2AR) and brain iron deficiency (BID) in RLS. These authors found a consistent upregulation of striatal A2AR in rats and rodents with severe BID (Gulyani et al

• In addition to furthering our understanding

  2020-08-04

  

  In addition to furthering our understanding of the properties of diacylglycerol kinases, there may be relevance of these findings to the role of endocannabinoids in neuronal function. 2-AG is an endocannabinoid that can arise from the DAG lipase catalyzed cleavage of SAG, the preferred substrate of

• Alamethicin The reported increased long chain fatty acid oxi

  2020-08-03

  

  The reported increased long-chain fatty Alamethicin oxidation (LC-FAO) in those cells can certainly aid OXPHOS, but studies interrogating the functional importance of LC-FAO to support M(IL-4) phenotypes have yielded conflicting results (Van den Bossche et al., 2017). The need for increased LC-FAO

• MTX is a major component of the curative treatment

  2020-08-03

  

  MTX is a major component of the curative treatment of childhood ALL, and the extent of accumulation of its active polyglutamates (MTXPG) determines its cytotoxicity and influences treatment response in childhood ALL. GGH converts long-chain MTXPG into shorter-chain MTXPG and ultimately into MTX, whi

• Similar to what is observed in rectal

  2020-08-03

  

  Similar to what is observed in rectal cancer surgery, erectile dysfunction after radical prostatectomy is associated with intraoperative injury to the nerves. Recovery of erectile function after such injury requires a certain convalescence period. PDE-5 inhibitors have been used to improve erectile

• Interestingly our analyses of human

  2020-08-03

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 1,3-PBIT dihydrobromide receptor showed homogeneous high expression of EBI2 compared with Th1 cells, which c

• In this work we aimed to deepen our knowledge

  2020-08-03

  

  In this work, we aimed to deepen our knowledge on the functional regulation of the malin–laforin complex. First, we focused our attention on the E2-conjugase that participates in the ubiquitination reaction. We found that the ubiquitin conjugating enzyme E2-N (UBE2N; Ubc13), one of the more than 38

• Efforts to identify Nurr agonists have been hampered

  2020-08-03

  

  Efforts to identify Nurr1 agonists have been hampered by major gaps in our understanding of the receptor\'s structure and regulation. In particular, the only reported crystal structure of the receptor (apo Nurr1), published over 15 years ago, reveals the canonical nuclear receptor (NR) ligand-bindin

• br Materials and experimental procedure br Results and

  2020-08-03

  

  Materials and experimental procedure Results and discussions Conclusions The performance of geopolymers made with MK partially substituted by RHA in the presence of 10 M sodium hydroxide solution was studied. From the investigations carried out, the following conclusions can be drawn: Co

• C527 TrypanosomaParasitic protozoans have been extensively i

  2020-08-03

  

  TrypanosomaParasitic protozoans have been extensively investigated due to the search for new effective drugs for the dangerous diseases they cause. Because mammalian mitochondria do not possess alternative dehydrogenase in the respiratory chain, these proteins have become a specific potential target

• No gross anatomical or histological alterations

  2020-08-03

  

  No gross anatomical or histological alterations have been observed in the brains of DDR1-deficient animals (E. Vilella and W.F. Vogel, unpublished results). Hearing loss is the only defect observed in the sensory nervous system of DDR1-deficient mice (Meyer zum Gottesberge et al., 2008). Meyer zum G

• The levels of circulating pro inflammatory cytokines

  2020-08-03

  

  The levels of circulating pro-inflammatory cytokines are markedly elevated in ESRD, and have been speculated to play an important role as causative factors in a number of uremic complications [37]. The impairment of phagocyte functions and deregulated cytokine productions are highly prevalent in CRF

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