• br Acknowledgements This work was supported by the FedEx Ins

  2023-09-05

  

  Acknowledgements This work was supported by the FedEx Institute of Technology at The University of Memphis (to DLB and ALP), NSF REU CHE 1156738 (to ALP in support of RSS), and NIHCA921060 (to GT). This material is based upon work supported by the National Science Foundation under Grant No. CHE-1

• HCC aetiology is multifactorial and the disease is

  2023-09-05

  

  HCC aetiology is multifactorial and the disease is often preceded by other conditions including liver fibrosis and cirrhosis that are associated with HCV, HBV, alcoholic and non-alcoholic hepatitis. The discovery of new therapeutic targets will require a greater understanding of the pathogenic mecha

• Although CP has been an important research subject in the

  2023-09-05

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular full article by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of

• While it is known that circulating LDL C levels are

  2023-09-05

  

  While it is known that circulating LDL-C levels are largely regulated by either controlling the rate of hepatic production of its triglyceride-rich precursor VLDL particle or the rate of LDLR-mediated LDL particle clearance [58], it should be noted that important differences exist between rodents an

• The apoptosis promoting Bcl family includes

  2023-09-05

  

  The apoptosis-promoting Bcl-2 family includes BH3-only proteins (e.g., Bim, Bid and Bad) and multiple-domain proteins (e.g., Bax and Bak). At the time of apoptosis stimulation (e.g., DNA damage), only the BH3-only protein is activated, directly or indirectly promoting Bax/Bak oligomerization, changi

• br Declaration of interest br Funding br Introduction The

  2023-09-05

  

  Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers

• Sustained release property is also associated with side effe

  2023-09-05

  

  Sustained release property is also associated with side effects reduction [16] that could be confirmed by histopathological analyzes. Massive infiltrating inflammatory cells, hyperproliferation of skin layers and keratin pearls, caused by DMBA and croton oil application [32] are attenuated in Imq-lo

• br Natriuretic peptides and neprilysin Left ventricular syst

  2023-09-05

  

  Natriuretic peptides and neprilysin Left ventricular systolic function, most commonly due to myocardial damage as a consequence of coronary artery disease, hypertension or both, and leading to sustained, pathological activation of the renin angiotensin tryptophan hydroxylase system (RAAS) and sy

• Introduction Induction of long term potentiation

  2023-09-05

  

  Introduction Induction of long-term potentiation (LTP), the cellular correlate of learning and memory, triggers profound changes in the structure and function of excitatory synapses by increasing dendritic spine size and synaptic strength. Significant progress has been made in understanding the int

• br Available treatment modalities for individuals with NAFLD

  2023-09-05

  

  Available treatment modalities for individuals with NAFLD There are several treatment modalities currently used or in clinical trials for individuals with NAFLD. The most widely recommended treatment is a lifestyle modification plan. As little as 5% weight loss has been shown to improve NASH hist

• Introduction A defining feature of

  2023-09-05

  

  Introduction A defining feature of cancer cells is disruption of the normal controls of the cell cycle; a tumor suppressor or inhibitor may act by restricting progression of the cell cycle. P27 (also known as cyclin-dependent kinase inhibitor 1B, P27, or Kip1) is a putative cell-cycle inhibitor pro

• br Actin cytoskeleton in protrusion Pushing force driving me

  2023-09-05

  

  Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing CK 666 filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lamellip

• Taniyama et al reported a female with infertility who

  2023-09-04

  

  Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of IVF phenylephrine hydrochloride was initiated using dexamethasone to con

• Signaling through Axl can lead

  2023-09-04

  

  Signaling through Axl can lead to activation of the PI3K/Akt and Ras/MAPK pathways which promote cellular phenotypes (e.g., transformation, migration) consistent with pro-survival and pro-metastatic effects., , Inhibition of Axl activity by a variety of approaches (including pharmacologic, dominant

• Axl has been reported to

  2023-09-04

  

  Axl has been reported to mediate cell-cell adhesion and sphere-growth [11], [18] and to be important for metastasis to secondary organs [12], [14], [20]. We found an Axl-dependent CCRCC-ability of sphere-formation and repopulation after non-adhesive growth. Axl-inhibited cells could not attach to ea

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