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Our results lead to the discovery and characterization
2023-09-26

Our results lead to the discovery and characterization of VvAAT2, a gene potentially involved in acetate accumulation in grape berries discovered through amino-acid feeding experiments. Incubation with exogenous amino acids has also been a key in the discovery of new genes affecting fruit aromas [13
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MT SGL encourages a individual feature selection based on th
2023-09-26

MT-SGL encourages (a) individual feature selection based on the utility of the features across all tasks with ℓ2,1-norm and (b) task specific group selection based on the utility of the group with G2,1-norm, i.e., Leonurine hydrochloride synthesis regions of interest (ROI) for that task. Unlike bas
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Using constant potential amperometry and electrochemical
2023-09-25

Using constant potential amperometry and electrochemical enzyme-based biosensors selective for choline—and, therefore, an accurate readout of Dehydrocostus Lactone release (Baker et al., 2015; Bruno et al., 2006a; Parikh et al., 2004, 2007)—tonic and phasic release of acetylcholine were measured si
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A rational approach for the design of
2023-09-25

A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a
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br Materials and methods br Results br Discussion In
2023-09-25

Materials and methods Results Discussion In the present study, we found that SSTR2, SSTR5, and DA2R proteins are expressed in ACTH-positive Suramin hexasodium salt synthesis in healthy canine pituitary glands, with particularly high positive cell ratios in the intermediate lobes. Somatosta
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It is reported that calpain
2023-09-25

It is reported that calpain-2 plays a critical role in BDNF-induced signaling and memory formation, and knockdown of calpain-2, but not calpain-1, completely suppresses BDNF-induced pathway activation and protein translation (Briz et al., 2013). BDNF prevents neuronal apoptosis or death (Ferrer et a
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In addition to attracting immune cells
2023-09-25

In addition to attracting immune cells to the site of injury, ROS also participate in proliferative responses during compensatory proliferation and regeneration. In Xenopus tadpoles, tail amputation induces sustained production of ROS over the span of regeneration, and decreasing ROS levels, especia
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The subnuclear localizations of redox regulators is also lar
2023-09-25

The subnuclear localizations of redox regulators is also largely unknown. The potential role of thiol reductases as transcription regulators or DNA repair molecules may suggest an association to DNA. In this way, the presence of a zinc finger domain potentially involved in protein/DNA interactions o
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In addition to differential expression of AR protein primari
2023-09-25

In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human Fmoc-Thr(tBu)-OH cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive bladder tumors,
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everolimus Introduction Lipoxygenases LOXs are key enzymes t
2023-09-25

Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic everolimus (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claesson, 20
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Both AD and dyslipidemias are global public health
2023-09-25

Both AD and dyslipidemias are global public health problems, and an increase in their incidence over the next decades is expected. Among many triggering elements, the increase in life expectancy is one of the main risk factors associated with the increase in the incidence of AD. Meanwhile, dyslipide
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In conclusion phenolic hydroxyl was introduced not only
2023-09-25

In conclusion, phenolic hydroxyl was introduced not only to C3 side chain but also to C6 or C7 position of the quinoxalinone core, resulting in a new group of ARIs candidates exhibiting antioxidant activity. Biological activity tests suggested that compounds were not only sufficient to inhibit ALR2
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AhR was proven to participate in carcinogenesis
2023-09-25

AhR was proven to participate in carcinogenesis. Its high expression was demonstrated in a variety of tumors, i.e. pancreatic, prostate, urinary tract, lung and papillary thyroid carcinoma (Safe et al., 2013, Mian et al., 2014). However, cell line studies showed variable AhR levels/responses. AhR kn
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In our study the expression levels of
2023-09-25

In our study, the expression levels of adiponectin and its receptors in the uteri, conceptuses, and throphoblasts were determined by the stage of early pregnancy. Therefore, it could be hypothesized that the adiponectin system is regulated by the local hormonal milieu. Hormonal regulation in the ute
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zcl mg br Conclusions br Acknowledgments This research was f
2023-09-25

Conclusions Acknowledgments This research was funded by the National Science Foundation Committee (NSFC) of China (Nos. 81171058 and 81471146) and Capital Development Scientific Research in China (Nos. 2011-5001-04 and 2014-4-5013). We are grateful for all of the participants who donated blood
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