• Preclinical models indicate roles for adiponectin in the mai

  2024-01-31

  

  Preclinical models indicate roles for adiponectin in the maintenance of hepatic lipid metabolism. Adiponectin overexpression prevents accumulation of triglycerides or the deleterious lipid metabolites diacylglycerols or ceramides [5,8]. Direct manipulation of adiponectin expression demonstrates a po

• Introduction Myasthenia gravis MG is an autoimmune disorder

  2024-01-30

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic 6-O-α-Maltosyl-β-cyclodextrin receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopat

• The UV vis and fluorescence spectra have been used

  2024-01-30

  

  The UV–vis and fluorescence spectra have been used to study the interaction between small chemical molecules and biomolecules (Punith and Seetharamappa, 2012). The UV Isochlorogenic acid C peak of the protein changes with the microenvironment of the chromophore. That is, the peaks may show a certai

• br Materials and methods br Results br

  2024-01-30

  

  Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se

• In the present study we sought to decipher

  2024-01-30

  

  In the present study we sought to decipher the role of ATP-citrate lyase and of the mitochondrial NADH-dependent Mae in the oleaginous yeast Y. lipolytica. Indeed, although this yeast is one of the major models for lipid metabolism, the function of these enzymes is still not clear. As the study of t

• br Mechanisms of GPCR internalization Like

  2024-01-30

  

  Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated 92 3 synthesis (CME) is the best characterized and ar

• Inflammations lead to the perturbation of aromatase enzyme w

  2024-01-30

  

  Inflammations lead to the perturbation of aromatase enzyme [112], which normally is responsible for a broad array of critical functions. Chemotherapy targets this enzyme, so this treatment option is never side-effect-free and not fully-effective. Therefore, the mankind should be careful so as not to

• In order to determine whether the faster Rh

  2024-01-30

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in TNP-ATP triethylammonium salt depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed th

• br Conclusion br References and recommended reading Papers

  2024-01-30

  

  Conclusion References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Nucleosome, the basic chromatin unit, is composed of DNA and core histones (H2A, H2B, H3 and H4) and organized into

• br Results The newly synthesized

  2024-01-30

  

  Results The newly synthesized leucine ureido derivatives were firstly evaluated for their enzymatic inhibition using porcine kidney APN (Microsomal, Biocol) with bestatin as the positive control (Table 1). One isoleucine ureido derivative 14 and phenylglycine ureido derivative 15 were also synthe

• Another issue is that the vast

  2024-01-30

  

  Another issue is that the vast majority of data from PET and CSF are from selected participants recruited through tertiary care dementia centers [176]. It is widely recognized that clinic-based participants differ from community-based studies, for example, the amount, type, and distribution of neuro

• There are several strengths and

  2024-01-30

  

  There are several strengths and weaknesses of the current investigation which merit consideration. Obviously, the current findings are important and less prone to bias than findings from traditional observational epidemiological studies, because causal investigations with the use of genetic variants

• Additionally we were prompted to validate the protective eff

  2024-01-30

  

  Additionally, we were prompted to validate the protective effect of ALDH3A1 by utilizing a human corneal model. Cornea is located in the anterior segment of the eye and thus, is constantly exposed to various environmental stressors that affect the cellular oxidative balance and consequently lead to

• With one exception all receptors for dopamine

  2024-01-29

  

  With one exception, all receptors for dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine are metabotropic receptors. The five metabotropic DA receptors (D1–D5) in the CNS are involved in motivation, pleasure, cognition, learning, memory, fine motor control, and modulate neuroen

• AdipoRon acts on the anti diabetic effects

  2024-01-29

  

  AdipoRon acts on the anti-diabetic effects of adiponectin, exhibiting its effect through the activation of AMPK and PPARα pathways via AdipoR1 and AdipoR2, respectively [23]. AdipoR activation is a promising treatment for diabetes, nonalcoholic fatty liver disease, and cardiovascular disease, demons

15940 records 206/1063 page Previous Next First page 上5页 206207208209210 下5页 Last page