• br Acknowledgements This work was supported by

  2025-02-11

  

  Acknowledgements This work was supported by the Victorian Government Operational Infrastructure Support Program. KAB is supported by the Mavis Robertson Fellowship from the National Breast Cancer Foundation (NBCF; ECF-16-004), by an NBCF Novel Concept Award (NC-14-011), and by NHMRC project grant

• In this study we showed that TRIM promotes ASK activation

  2025-02-11

  

  In this study, we showed that TRIM48 promotes ASK1 activation through ubiquitination-dependent degradation of a negative regulator of ASK1 activation, protein arginine methyltransferase 1 (PRMT1). Knocking down TRIM48 suppressed oxidative-stress-induced cell death mediated by ASK1, and the additiona

• We demonstrated clearly that the overexpression of

  2025-02-11

  

  We demonstrated clearly that the overexpression of sFlt-1 significantly increased arginase luteolin and enhanced arginase activity in HUVECs (Fig. 3). NO formation is related inversely to serum levels of sFlt-1 in preeclampsia [11]. The disorder of NO formation, which was involved in hypertension an

• The diversity of metabolic adaptations employed

  2025-02-11

  

  The diversity of metabolic adaptations employed by cancer cells in response to rapidly changing conditions, contributes to their biological aggressiveness and therapeutic resistance by enabling them to proliferate when nutrients are plentiful and to shift their resources to survival when nutrients a

• In the previous study we demonstrated the

  2025-02-10

  

  In the previous study, we demonstrated the importance of the mPFC postsynaptic 5-HT1A receptor in the sustained antidepressant effects, because a sustained antidepressant effect was obtained with intra-mPFC injection, but not systemic injection of 8-OH-DPAT, a 5-HT1A receptor agonist (Fukumoto et a

• Though we have proved that VA

  2025-02-10

  

  Though, we have proved that VA could suppress hepatic gluconeogenesis, the mechanisms of VA on gluconeogenesis in vivo and in vitro remain unclear. AMP-activated protein kinase (AMPK), which is called an energy receptor enzyme, is widely expressed in liver and other tissues [23]. AMPK has become ano

• The adult muscle type acetylcholine receptor AChR

  2025-02-10

  

  The adult muscle-type Actinomycin D receptor (AChR), the exemplar pLGIC, is a heteropentamer comprising two α subunits, and one each of the β, δ, and ɛ subunits (Sine, 2012). These five subunits come together in a counterclockwise α-ɛ-α-δ-β arrangement (Figure 1A). Binding of acetylcholine to the A

• Given the profound expression of HT A and HT

  2025-02-10

  

  Given the profound Madecassic acid of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reversib

• Among the AXL positive tumors that we screened the TNBC

  2025-02-10

  

  Among the AXL-positive tumors that we screened, the TNBC cell line MDA-MB-231 showed the highest AXL expression level. Additionally, AXL protein levels were higher in TNBC patient samples than in other breast cancers. Considering the difficulty of, and the urgent need for, effective treatments of TN

• Pyrimidine is the important pharmacology core in many

  2025-02-10

  

  Pyrimidine is the important pharmacology core in many Aurora inhibitors, such as VX-680, ENMD-2076, CYC-116 and ENMD-2076 [12]. To identify additional effective Aurora inhibitors, we designed a series of 2,4-diaminopyrimidine compounds, our modeling studies suggested that the histone demethylation

• br Results br Discussion The

  2025-02-10

  

  Results Discussion The A. nidulans Aurora kinase displays diverse locations during mitosis and we show here that it also locates to hyphal regions where septa subsequently form, to the septal pore region of newly formed septa and displays a Stability and size of mCherry protein specific locat

• br Introduction The process of mitosis is highly

  2025-02-10

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the Safingol synthesis resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in reg

• In plants altered expression of Aurora kinases

  2025-02-10

  

  In plants, altered expression of Aurora kinases results in impaired meiotic divisions followed by the formation of aneuploid or polyploid progenies [21]. This observation is interesting from an evolutionary point of view because it can be assumed that, during evolution, the influence of biotic and a

• Phosphoinositide kinase PI K Akt

  2025-02-10

  

  Phosphoinositide 3-kinase (PI3K)/Akt has been well demonstrated in the protection of myocardial cell against IR injury via increasing cardiomyocyte survival, inhibiting excessive autophagy, et al. (Kong et al., 2016). The Solu-Medrol of ERK1/2 also involves in the regulation of cardiac myocyte surv

• Chromatin proteins play important roles in gene expression a

  2025-02-10

  

  Chromatin proteins play important roles in gene expression and DNA repair. The importance of chromatin composition on gene expression is exemplified by X-inactivation, where one of the two X chromosomes in female mammalian KT203 is transcriptionally silenced by heterochromatin , , , . In the ATR pa

15886 records 15/1060 page Previous Next First page 上5页 1112131415 下5页 Last page